Table 1.

CUR61414 blocks proliferation and induces apoptosis in basaloid lesions in mouse embryonic skin punches

Treatment of skin punches	Mitotic index, %*	Apoptotic index, %†
Vehicle‡	35.63  ± 5.38	4.83  ± 0.92
CUR61414 (1 μM)	10.46  ± 4.13	31.75  ± 4.17
CUR61414 (5 μM)	7.71  ± 2.63	34.33  ± 6.71

Skin punches were first treated with Shh^OCT followed by treatment with [Shh^OCT + Vehicle] or [Shh^OCT + CUR61414] for another 48 h. The average number of cells per lesion was 24 (100%). 

^*Percent PCNA-labeled cells per lesion. 

^† Percent TUNEL-labeled cells per lesion. 

^‡ 0.1–0.5% DMSO.