Table 2.
CUR61414 induces regression of UV-induced basaloid lesions in skin from adult Ptc+/−-lacZ heterozygote transgenic mice
| Experiment number | Treatment of skin punches* | Number of basaloid lesions† |
|---|---|---|
| 1 | Vehicle | 50.50 ± 5.30 |
| CUR61414 | 15.75 ± 5.70 | |
| 2 | Vehicle | 12.00 ± 1.41 |
| CUR61414 | 4.00 ± 0.82 | |
| 3 | Vehicle | 20.25 ± 6.20 |
| CUR61414 | 9.75 ± 3.60 |
Four-millimeter skin punches were generated from the irradiated mice and cultured for 96 h in vitro, with vehicle (0.5% DMSO) or CUR61414 (5 μM).
Average number of lesions across four skin punches.