Figure 2.
Influence of the soluble guanylyl cyclase inhibitor, NS 2028, on vascular responsiveness. (A) Increase in tone induced by the application of 1 μM NS 2028 to vessels precontracted with 0.1–1 μM PGF2α to between 10% and 50% of the maximum. Data are presented as the mean ± SEM of eight separate experiments. ∗, P < 0.05, indicating a significant NS 2028-induced increase in vascular tone. (B) Effect of solvent (■) and 1 μM NS 2028 (•) on the ACh-induced relaxation of aortic rings maximally contracted with phenylephrine. Data are presented as the mean ± SEM of eight separate experiments. ∗∗, P < 0.01, indicating a significant difference between the solvent and NS 2028-treated rings.