Figure 4.

Highlights of key changes in cell cycle, differentiation, and metabolism-related transcripts. (A) Representative steps from pathways involved in cell cycle regulation and myogenesis. Significantly underexpressed (in red) and overexpressed (in green) genes were identified by using fold and t test analysis (Table 3). The CCND2/CDK4 pathway seems to be overall promoted, whereas the c-Fos and c-Jun pathways appear inhibited at the transcriptional level. Myogenesis-related genes are underexpressed. (B) Overall underexpression of key enzymes from the glucose and glycogen metabolic pathways (Table 3).