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MDX-CTLA-4 stimulated melanocyte immune recognition. (A) Reticular erythematous rash. (B) Perivascular lymphocyte infiltrate extending into epidermis with interface dermatitis. (C) CD4+ T cells apposed to dying melanocytes. (D) CD8+ T cells apposed to dying melanocytes. (Magnification: ×125, B; ×250, C and D.)
