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MDX-CTLA-4 induced extensive tumor necrosis in vaccinated patient 2. (A and B) Tumor necrosis with granulocytes and lymphocytes. (C) CD4+ T cells. (D) CD8+ T cells. (E) CD20+ B cells. (F) Vasculopathy with perivascular and intramural lymphoid infiltrates associated with luminal thrombosis. (Magnification: ×125, A; ×250, B–F.)
