Figure 2.

Analysis of visual function by ERG in wild-type and abcr^−/− mice after treatment with isotretinoin. (A) b-wave amplitudes elicited in wild-type mice with a dim probe flash (−0.91 log scot td-s) at the indicated times after a 40% photobleach divided by the dark-adapted b-wave amplitude. The mice received a single injection of isotretinoin (40 mg/kg) 1 hr before the photobleach (red circles, n = 7) or received no treatment (blue circles, n = 4). (B) Same protocol as in A except mice were abcr^−/− genotype (red circles, n = 4; blue circles, n = 5). (C) Rm_P3 amplitudes (derived from the leading edge of the a-wave) elicited in wild-type mice with a bright probe flash (3.11 log scot td-s) at the indicated times after a 40% photobleach divided by the dark-adapted Rm_P3 amplitude. Treatment protocol was similar to A (red circles, n = 7; blue circles, n = 7). (D) Same protocol as in C except mice were abcr^−/− genotype (red circles, n = 9; blue circles, n = 9). Error bars show SD.