Figure 1.

Fate of infected lymphocytes with M184V mutant and 184M wild-type viruses based on different models of cell clearance and under different treatment conditions. Cells harboring 184M virus are shown as open circles, and cells harboring 184V virus are shaded circles. The expected results shown are theoretical outcomes in isolation from all other processes. (a) Uniform decay predicted by current models which assume a homogeneous population and in the absence of effects due to disproportionate reseeding. (b) Replenishment of reservoir on HAART with lamivudine. (c) Replenishment of reservoir on HAART without lamivudine. (d) Cell loss caused by senescent death. (e) Preferential loss of latently infected cells that were more recently established.