Figure 3.

Structure of the ARG1 protein. (A) A scale-drawn representation of the putative domains (shaded rectangles) within the ARG1 protein (open rectangle). The locations of the arg1–1 and arg1–2 mutations are depicted by arrows. TM, transmembrane domain. (B–C) Amino acid sequence alignments of the ARG1 J domain (B) and coiled-coil region (C) with the corresponding domains from other proteins (49–53, 58–63). The name of the protein and the contributing organism is to the right of the sequences, whereas the beginning positions of the sequences within the protein are listed to the left. Amino acid residues within the black boxes are identical to the corresponding ARG1 residue, whereas shaded residues are conserved, as determined by the blosom 62 substitution matrix (64). Alignments were made by using the DNAstar program dna*. H. Ch., Heavy Chain.