Figure 2.

Effects of 100 μM dichloroacetate on rates of glucose and lactate oxidation to CO₂ and lactate release into extracellular medium by neurons and astroglia in vitro. Bar heights and error bars represent mean rates ± SEM of glucose oxidation to CO₂ (A), lactate oxidation to CO₂ (B), or lactate release (C) determined in four experiments, in each of which each point was determined in quadruplicate. †, P < 0.05; ††, P < 0.01, for comparison of absolute differences between control and dichloroacetate-treated groups. *, P < 0.05; **, P < 0.01, for comparisons between the logarithms of the percent differences between control and dichloroacetate-treated groups; the percent differences are the means of the individual percent differences in the experiments and not the percent difference between the means.