Table 1.
Physiological variables in rats in two series of studies on effects of dichloroacetate in vivo
| Variable | Resting ICMRglc
|
Functional activation of ICMRglc
|
||
|---|---|---|---|---|
| Saline controls (n = 9) | Dichloroacetate (50 mg/kg) (n = 6) | Saline controls (n = 8) | Dichloroacetate (50 mg/kg) (n = 7) | |
| Mean arterial blood pressure, mm Hg | 122 ± 2 | 115 ± 2* | 122 ± 2 | 117 ± 2 |
| Arterial pCO2, mm Hg | 37 ± 1 | 38 ± 1 | 35 ± 1 | 35 ± 1 |
| Arterial pO2, mm Hg | 80 ± 2 | 84 ± 2 | 87 ± 2 | 87 ± 3 |
| Arterial pH | 7.45 ± 0.01 | 7.44 ± 0.01 | 7.46 ± 0.01 | 7.44 ± 0.01 |
| Arterial plasma glucose concentration, mM | 7.1 ± 0.2 | 6.2 ± 0.2** | 7.2 ± 0.3 | 5.9 ± 0.2** |
| Arterial plasma lactate concentration, mM | ND | ND | 1.4 ± 0.1 | 1.0 ± 0.1** |
Values are means ± SEM of number (n) of animals indicated. ND, not determined.
*
, P < 0.05;
**
, P < 0.01 compared to saline-treated controls.