Skip to main content
. 2003 Apr 4;100(8):4915–4920. doi: 10.1073/pnas.0537849100

Figure 3.

Figure 3

Prenatal WIN selectively suppresses LTP maintenance but not its induction. (A) Time course of the averages of f-EPSP slopes from slices obtained from 40-day-old offspring of vehicle-treated (●) and WIN-treated dams (○). Values of f-EPSP slopes have been normalized to the pretetanus period. Each point represents the average ± SEM of 10 consecutive responses taken every 5 min. Just after tetanization (given at time −5 min), the values of f-EPSP first potentiation (i.e., the PTP) were 255.90 ± 18.07 and 229.18 ± 23.43% for vehicle- and WIN-treated groups, respectively (not significant, Student's t test). (B) Duration of LTP. Evoked f-EPSPs were considered potentiated until their slope was ≥20% with respect to baseline. For the vehicle group, LTP duration was estimated by fitting analysis of the curve in A to calculate the interception point where this curve asymptotically subsided to a value of +20%. It occurred at 334.45 ± 25.36 min after tetanus. However, the curve describing LTP expression of the WIN-treated group (data from A) returned to +20% of baseline in 136.87 ± 12.18 min. Bars represent the mean ± SEM obtained from 22 and 21 slices from vehicle- and WIN-exposed rats, respectively. *, P < 0.001 vs. vehicle (Student's t test).