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. 1982 Oct;50(1):171–177.

C-peptide antibodies induced by bovine insulin therapy.

W G Reeves, C A Douglas
PMCID: PMC1536853  PMID: 6756729

Abstract

Antibodies reactive with the C-peptide portion of proinsulin can be detected in the sera of patients on conventional bovine insulin regimes which include the soluble form. Direct and competitive binding studies demonstrate that C-peptide antibodies show species specificity but do not recognize free homologous C-peptide. This is likely to be due to conformational change following cleavage of C-peptide from the proinsulin molecule. Examination of sera from a large group of patients established on a standard insulin regime shows that C-peptide and insulin antibody levels do not correlate with each other and are likely to show different patterns of genetic control.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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