Skip to main content
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1983 Feb;51(2):299–304.

Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid.

M J Welch, S Fong, J Vaughan, D Carson
PMCID: PMC1536905  PMID: 6601551

Abstract

Vaccination of normal adults with tetanus toxoid induced a two-three-fold rise in the frequency of IgM anti-IgG (rheumatoid factor, RF) B lymphocytes inducible by the polyclonal B cell activator, Epstein-Barr virus. The increase in IgM-RF precursors occurred earlier, was greater in magnitude, and was more sustained than the change in plasma IgM-RF. It was associated with a rise in total IgM levels, and correlated positively with the magnitude of the IgG anti-tetanus antibody response, but not with levels of circulating immune complexes. The ability of apparently innocuous infections and immunizations to increase the frequency of IgM-RF precursor B lymphocytes may be the reason for the previously noted expansion in this autoreactive B cell pool between birth and adulthood.

Full text

PDF
299

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Birkeland S. A. Cryopreservation of human lymphocytes for sequential testing of immune competence. J Immunol Methods. 1980;35(1-2):57–67. doi: 10.1016/0022-1759(80)90150-7. [DOI] [PubMed] [Google Scholar]
  2. Brenner M. K., Munro A. J. Human anti-tetanus antibody response in vitro: autologous and allogeneic T cells provide help by different routes. Clin Exp Immunol. 1981 Oct;46(1):171–177. [PMC free article] [PubMed] [Google Scholar]
  3. Carson D. A., Bayer A. S., Eisenberg R. A., Lawrance S., Theofilopoulos A. IgG rheumatoid factor in subacute bacterial endocarditis: relationship to IgM rheumatoid factor and circulating immune complexes. Clin Exp Immunol. 1978 Jan;31(1):100–103. [PMC free article] [PubMed] [Google Scholar]
  4. Fong S., Tsoukas C. D., Frincke L. A., Lawrance S. K., Holbrook T. L., Vaughan J. H., Carson D. A. Age-associated changes in Epstein-Barr virus-induced human lymphocyte autoantibody responses. J Immunol. 1981 Mar;126(3):910–914. [PubMed] [Google Scholar]
  5. Kreisler M. J., Hirata A. A., Terasaki P. I. Cytotoxins in disease. 3. Antibodies against lymphocytes produced by vaccination. Transplantation. 1970 Nov;10(5):411–415. [PubMed] [Google Scholar]
  6. Lefkovits I. Induction of antibody-forming cell clones in microcultures. Eur J Immunol. 1972 Aug;2(4):360–366. doi: 10.1002/eji.1830020412. [DOI] [PubMed] [Google Scholar]
  7. Mogensen C. E. The glomerular permeability determined by dextran clearance using Sephadex gel filtration. Scand J Clin Lab Invest. 1968;21(1):77–82. doi: 10.3109/00365516809076979. [DOI] [PubMed] [Google Scholar]
  8. Rhodes K., Scott A., Markham R. L., Monk-Jones M. E. Immunological sex differences. A study of patients with rheumatoid arthritis, their relatives, and controls. Ann Rheum Dis. 1969 Mar;28(2):104–120. doi: 10.1136/ard.28.2.104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. SVEC K. H., DINGLE J. H. THE OCCURENCE OF RHEUMATOID FACTOR IN ASSOCIATION WITH ANTIBODY RESPONSE TO INFLUENZA A2(ASIAN) VIRUS. Arthritis Rheum. 1965 Aug;8:524–529. doi: 10.1002/art.1780080406. [DOI] [PubMed] [Google Scholar]
  10. Sabharwal U. K., Vaughan J. H., Fong S., Bennett P. H., Carson D. A., Curd J. G. Activation of the classical pathway of complement by rheumatoid factors. Assessment by radioimmunoassay for C4. Arthritis Rheum. 1982 Feb;25(2):161–167. doi: 10.1002/art.1780250208. [DOI] [PubMed] [Google Scholar]
  11. Tsoukas C. D., Carson D. A., Fong S., Pasquali J. L., Vaughan J. H. Cellular requirements for pokeweed mitogen-induced autoantibody production rheumatoid arthritis. J Immunol. 1980 Sep;125(3):1125–1129. [PubMed] [Google Scholar]
  12. Zubler R. H., Nydegger U., Perrin L. H., Fehr K., McCormick J., Lambert P. H., Miescher P. A. Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease. J Clin Invest. 1976 May;57(5):1308–1319. doi: 10.1172/JCI108399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. van Snick J. L., Masson P. L. Age-dependent production of IgA and IgM autoantibodies against IgG2a in a colony of 129/Sv mice. J Exp Med. 1979 Jun 1;149(6):1519–1530. doi: 10.1084/jem.149.6.1519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. van Snick J. L., Masson P. L. Incidence and specificities of IgA and IgM anti-AgG autoantibodies in various mouse strains and colonies. J Exp Med. 1980 Jan 1;151(1):45–55. doi: 10.1084/jem.151.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES