Conservation across the AR gene. Plot illustrating the conservation of the AR using the domain alignment. The different lines illustrate the approximate locations of the three major domains across the AR. Domains are defined as: the N-terminal domain (NTD, codons 1–556), the DNA binding domain (DBD, 557–623), and the ligand binding domain (LBD, 666–918). The NTD is dashed, the DBD is dotted, and the LBD is solid.