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. 2002 Mar;76(5):2225–2232. doi: 10.1128/jvi.76.5.2225-2232.2002

FIG. 3.

FIG. 3.

Total virus-neutralizing antibody titers in mice at 2 weeks post-FV infection. The neutralizing antibody titer was considered to be the highest dilution at which more than 75% of the input virus was neutralized. (A) The difference between the titers in B6 and the titers in B6.IFN-γ−/− mice was significant as determined by the Mann-Whitney test (P = 0.0081). Significantly more B6.IFN-γ−/− mice had detectable titers compared to wild-type B6 mice (Fisher's exact test, P = 0.0157). (B) The IFN-γ-depleted mice had significantly higher virus-neutralizing antibody titers than did the control mice (Mann-Whitney test, P = 0.0411). Also, significantly more IFN-γ-depleted mice had detectable titers compared to wild-type B6 mice (Fisher's exact test, P = 0.0303).