TABLE 1.
Tissue-specific viral antigen expression during acute FV infectiona
| Mouse strain | Mean % antigen-positive cells ± SD at:
|
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|---|---|---|---|---|---|---|---|
| 1 wk postinfectionb in:
|
2 wks postinfectionc in:
|
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| Spleen | Bone marrow | Blood cells | Spleen | Bone marrow | Blood cells | ||
| B6 | 7.9 ± 2.6 | 11.6 ± 6.6 | 0.5 ± 0.3d | 12.8 ± 8.9 | 20.4 ± 6.8 | 0.5 ± 0.3d | |
| B6.IFN-γ−/− | 11.4 ± 5.3 | 22.1 ± 9.4 | 6.0 ± 3.8 | 1.5 ± 2.1 | 4.3 ± 8.4 | 1.5 ± 2.0 | |
a
All tissues were examined by flow cytometry as single-cell suspensions of nucleated, live cells. The numbers of mice in each group were as follows at 1 week postinfection: B6.IFN-γ−/− (n = 6) and B6 (n = 6). The numbers of mice in each group were as follows at 2 weeks postinfection: B6.IFN-γ−/− (n = 11) and B6 (n = 15).
b
P = 0.3095, 0.0256, and 0.0002 for spleen, bone marrow, and blood cells, respectively.
c
P = <0.0001, 0.0006, and 0.6070 for spleen, bone marrow, and blood cells, respectively.
d
The percentage of cells that stained positive for antigen in the infected B6 mice was below or equivalent to the background staining in naive mice.