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. 2002 Mar;76(5):2375–2383. doi: 10.1128/jvi.76.5.2375-2383.2002

FIG. 5.

FIG. 5.

Reconstitution of the splenic follicular microarchitecture with wild-type B cells restores impaired, early LCMV production in RAG2−/− mice. (A) Various mice or chimeras were infected with 500 PFU of LCMV-WE i.v., and 4 days later LCMV titers were determined. Bars represent mean values for n animals. Error bars show the range (for n = 2) or standard error of the mean (for n = 4). (B) Representative examples of immunohistochemical analysis with MAdCAM-1+ antibodies and LCMV GP-specific in situ hybridization of C57BL/6 (a), RAG2−/− (b), B-cell-reconstituted RAG2−/− (c), and TNF-α−/− LTα−/− B-cell-reconstituted RAG2−/− TNF-α−/− LTα−/− (d) mice at 4 days after LCMV-WE infection. Magnification, ×125.

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