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. 1975 Feb;19(2):209–217.

The interaction of rheumatoid factor with hepatitis B surface antigen-antibody complexes.

J A Markenson, C A Daniels, A L Notkins, J H Hoofnagle, J Gerety, L F Barker
PMCID: PMC1538083  PMID: 1212797

Abstract

A solid phase radioimmunoassay was developed in which the hepatitis B surface antigen was adsorbed to the surface of plastic beads. When the antigen-coated beads were incubated with human IgG antibody against hepatitis B surface antigen, immune complexes were formed on the solid phase surface. IgM rheumatoid factor was found to bind to the hepatitis B surface antigen-antibody complexes but not to the antigen or the IgG antibody alone. Since both hepatitis B surface antigen-antibody complexes and rheumatoid factor are commonly present in type B viral hepatitis, it is suggested that rheumatoid factor may play a role in the pathogenesis of this viral disease in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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