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Acute viral replication of SB5, 333-vhsB, 333d41, and 333-vhsBR in mouse brain. Mice were infected intracerebrally with 5 × 102 PFU of virus. Each data point reflects the geometric mean PFU of virus per brain ± SEM from two independent experiments. In total, data points represent at least four brains per virus per day. The limit of detection, indicated by the dashed line, is 40 PFU/ml.
