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. 1980 Mar;39(3):570–575.

Circulating immune complexes in onchocerciasis.

R Paganelli, J L Ngu, R J Levinsky
PMCID: PMC1538140  PMID: 7379329

Abstract

Circulating immune complexes were detected in sera of patients with both localized and generalized onchocerciasis by a 125I-Clq binding assay but not by the IgG latex agglutination inhibition method. Gel filtration of sera demonstrated high molecular weight Clq-reactive material(greater than 2 x 10(6) Daltons) which contained IgM but no IgG. Antibody titres to Onchocerca volvulus antigen were higher in patients with generalized disease than in those with the localized form. The lack of correlation between antibody titres and levels of immune complexes suggests that these immune complexes contain antigens other than those derived exclusively from the parasite. Although few of the symptoms of this disease are likely to be due to deposition of circulating immune complexes, the depression of delayed hypersensitivity reactions to the parasite found in patients with generalized onchocerciasis may be due to IgM immune complexes exerting an immuno-regulatory role on T cell function.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Askonas B. A., Corsini A. C., Clayton C. E., Ogilvie B. M. Functional depletion of T- and B-memory cells and other lymphoid cell subpopulations-during trypanosomiasis. Immunology. 1979 Feb;36(2):313–321. [PMC free article] [PubMed] [Google Scholar]
  2. Bartlett A., Bidwell D. E., Voller A. Preliminary studies on the application of enzyme immunoassay in the detection of antibodies in onchocerciasis. Tropenmed Parasitol. 1975 Sep;26(3):370–374. [PubMed] [Google Scholar]
  3. Bloom B. R. Games parasites play: how parasites evade immune surveillance. Nature. 1979 May 3;279(5708):21–26. doi: 10.1038/279021a0. [DOI] [PubMed] [Google Scholar]
  4. Gibson D. W., Connor D. H. Onchocercal lymphadenitis: Clinicopathologic study of 34 patients. Trans R Soc Trop Med Hyg. 1978;72(2):137–154. doi: 10.1016/0035-9203(78)90049-4. [DOI] [PubMed] [Google Scholar]
  5. Hayward A. R., Layward L., Lydyard P. M., Moretta L., Dagg M., Lawton A. R. Fc-receptor heterogeneity of human suppressor T cells. J Immunol. 1978 Jul;121(1):1–5. [PubMed] [Google Scholar]
  6. Houba V., Brown K. N., Allison A. C. Heterophile antibodies, M-antiglobulins and immunoglobulins in experimental trypanosomiasis. Clin Exp Immunol. 1969 Jan;4(1):113–123. [PMC free article] [PubMed] [Google Scholar]
  7. Hudson K. M., Byner C., Freeman J., Terry R. J. Immunodepression, high IgM levels and evasion of the immune response in murine trypanosomiasis. Nature. 1976 Nov 18;264(5583):256–258. doi: 10.1038/264256a0. [DOI] [PubMed] [Google Scholar]
  8. Jayawardena A. N., Waksman B. H. Suppressor cells in experimentally trypanosomiasis. Nature. 1977 Feb 10;265(5594):539–541. doi: 10.1038/265539a0. [DOI] [PubMed] [Google Scholar]
  9. Klein F., Mattern P., Bosch HJ vd Experimental induction of rheumatoid factor-like substances in animal trypanosomiasis. Clin Exp Immunol. 1970 Dec;7(6):851–863. [PMC free article] [PubMed] [Google Scholar]
  10. Kobayakawa T., Louis J., Izui S., Lambert P. H. Autoimmune response to DNA, red blood cells, and thymocyte antigens in association with polyclonal antibody synthesis during experimental African trypanosomiasis. J Immunol. 1979 Jan;122(1):296–301. [PubMed] [Google Scholar]
  11. Meyers W. M., Neafie R. C., Connor D. H. Onchocerciasis: invasion of deep organs by Onchocerca volvulus. Am J Trop Med Hyg. 1977 Jul;26(4):650–657. doi: 10.4269/ajtmh.1977.26.650. [DOI] [PubMed] [Google Scholar]
  12. Ngu J. L., Blackett K. Immunological studies in onchocerciasis in Cameroon. Trop Geogr Med. 1976 Jun;28(2):111–120. [PubMed] [Google Scholar]
  13. Ngu J. L. Immunological studies on onchocerciasis. Varying skin hypersensitivity and leucocyte migration inhibition in a clinical spectrum of the disease. Acta Trop. 1978 Sep;35(3):269–279. [PubMed] [Google Scholar]
  14. Somorin A. O., Heiner D. C., Ajugwo R. E. Immunoglobulin E in Nigerian onchocerciasis. Am J Trop Med Hyg. 1977 Sep;26(5 Pt 1):872–876. doi: 10.4269/ajtmh.1977.26.872. [DOI] [PubMed] [Google Scholar]
  15. Zubler R. H., Lange G., Lambert P. H., Miescher P. A. Detection of immune complexes in unheated sera by modified 125I-Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of the test to systemic lupus erythematosus. J Immunol. 1976 Jan;116(1):232–235. [PubMed] [Google Scholar]

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