TABLE 1.
Variation in HLA-B35-restricted influenza A virus epitope NP418-426
| Sequencea | Yr(s) of isolation | Virus subtype | No. of virusesb | Epitope name |
|---|---|---|---|---|
| LPFDRPTIM | Before 1933 | H1N1 | 1 | |
| -----T--- | 1934 | H1N1 | 1 | |
| ----KT--- | 1940-1957 | H1N1/H2N2 | 6 | |
| ----K---- | 1957-1972 | H2N2/H3N2 | 7 | NP418-426/1957 |
| ----KS--- | 1972-1978 | H3N2 | 12 | NP418-426/1972 |
| ----KS-V- | 1977 | H3N2 | 1 | |
| ---EKS--- | 1983 | H3N2 | 1 | |
| ---EKS-V- | 1980-present | H3N2 | 35 | NP418-426/1980 |
a
A dash indicates identity with amino acid at same position in first sequence.
b
Number of viruses with the reported sequence in the influenza sequence database (http://www.flu.lanl.gov). Influenza A viruses (H1N1) were excluded from the analysis from 1977, the year that viruses of this subtype were reintroduced.