TABLE 2.
Binding affinity of NP418-426 peptide to HLA-B*3501
| Peptide | Sequence | IC50 (μM)a |
|---|---|---|
| NP418-426/1957 | LPFDKPTIM | 1.3-2.0 |
| NP418-426/1972 | LPFDKSTIM | 1.1-2.0 |
| NP418-426/1980 | LPFEKSTVM | 0.9-1.3 |
| M1128-135b | ASCMGLIY | >20 |
a
Capacity of binding to HLA-B*3501 is expressed as the concentration (micromolar) of peptide able to inhibit binding of the fluorescein isothiocyanate-labeled reference peptide by 50% (32) based on two assays.
b
HLA-B35-restricted influenza virus epitope from the matrix protein with a reported low binding affinity (10).