TABLE 1.

The host range of an ENTV vector is restricted compared to that of a JSRV vector^a

Species	Target cells	ENTV vector titer	JSRV vector titer
Sheep	SSF	5 × 103	6 × 105
Human	HT-1080	<10b	3 × 104
	IB3	<2	4 × 104
	293	5 × 102	4 × 104
	HeLa	<2	10
Monkey	Vero	<2	1 × 105
Dog	D17	<2	1 × 104
Bovine	MDBK	<2	2 × 103
Rabbit	RbTE	<2	2 × 103
Cat	G355	<2	20
Rat	208F	<2	<2
Hamster	A23	<2	<2
Mouse	NIH 3T3	<10b	<10b

^aTarget cells were exposed to the LAPSN vector with an ENTV pseudotype (produced from PN172/LAPSN cells) or with a JSRV pseudotype (produced from PJ4/LAPSN cells). Vector titers are expressed in AP⁺ FFU per except for HeLa cells, for which titers are expressed in G418-resistant CFU per ml due to the high level of endogenous heat-stable AP in HeLa cells, which precludes detection of vector-encoded AP. Results are means of at least two experiments.

^bLow-level transduction was detected in some assays.