Skip to main content
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1975 Jul;21(1):47–53.

Increased proliferation of T lymphocytes in the blood of patients with Hodgkin's disease.

C Huber, G Michlmayr, M Falkensamer, U Fink, G Zur Nedden, H Braunsteiner, H Huber
PMCID: PMC1538248  PMID: 1081022

Abstract

We investigated the number of DNA-synthesizing T lymphocytes in the blood of patients with Hodgkin's disease, with infectious mononucleosis and in normal controls. T cells were characterized by their ability to form rosettes with unsensitized neuramidase-treated sheep red blood cells. Cells in DNA synthesis were evaluated autoradiographically after in vitro incubation with [3H]thymidine. Our results indicated a preferential proliferation of T lymphocytes in the blood of patients with Hodgkin's disease and infectious mononucleosis and suggested an increased turnover of these cells.

Full text

PDF
47

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bianco C., Patrick R., Nussenzweig V. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J Exp Med. 1970 Oct 1;132(4):702–720. doi: 10.1084/jem.132.4.702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cowther D., Fairley G. H., Sewell R. L. Significance of the changes in the circulating lymphoid cells in Hodgkin's disease. Br Med J. 1969 May 24;2(5655):473–477. doi: 10.1136/bmj.2.5655.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Crowther D., Fairley G. H., Sewell R. L. Lymphoid cellular responses in the blood after immunization in man. J Exp Med. 1969 May 1;129(5):849–869. doi: 10.1084/jem.129.5.849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dickler H. B., Siegal F. P., Bentwich Z. H., Kunkel H. G. Lymphocyte binding of aggregated IgG and surface Ig staining in chronic lymphocytic leukaemia. Clin Exp Immunol. 1973 May;14(1):97–106. [PMC free article] [PubMed] [Google Scholar]
  5. Fairley G. H. Circulating lymphoid cells in Hodgkin's disease. Natl Cancer Inst Monogr. 1973 May;36:95–98. [PubMed] [Google Scholar]
  6. Grey H. M., Rabellino E., Pirofsky B. Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypogammaglobulinemia, cellular immune deficiency, and chronic lymphatic leukemia. J Clin Invest. 1971 Nov;50(11):2368–2375. doi: 10.1172/JCI106735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Huber C., Asamer H., Kurz R., Huber H., Braunsteiner H. Zytologischer Immunglobulinnachweis an DNS-synthetisierenden Blutlymphozyten von Patienten mit Virusinfektionen. Acta Haematol. 1971;45(1):23–28. doi: 10.1159/000208603. [DOI] [PubMed] [Google Scholar]
  8. Huber C., Dworzak E., Fink U., Michlmayr G., Brunsteiner H., Huber H. Receptor sites for aggregated gammaglobulin (AGG) on lymphocytes in lymphoproliferative diseases. Br J Haematol. 1974 Aug;27(4):643–654. doi: 10.1111/j.1365-2141.1974.tb06631.x. [DOI] [PubMed] [Google Scholar]
  9. Huber C., Huber H., Schmalzl F., Lederer B., Bütterich D., Braunsteiner H. DNS-ynthese in Blut-Lymphozyten beim malignen Lymphogranulom. Acta Haematol. 1970;44(4):222–232. doi: 10.1159/000208683. [DOI] [PubMed] [Google Scholar]
  10. Huber C., Kurz R., Asamer H., Huber H., Braunsteiner H. Die Differenzierung menschlicher Blutlymphocyten mit serologischen und autoradiographischen Methoden. II. Ergebnisse bei primären und symptomatischen Immunglobulinmangelzuständen. Klin Wochenschr. 1974 Feb 1;52(3):127–133. doi: 10.1007/BF01620750. [DOI] [PubMed] [Google Scholar]
  11. Jondal M., Holm G., Wigzell H. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972 Aug 1;136(2):207–215. doi: 10.1084/jem.136.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Michlmayr G., Huber C., Fink U., Falkensammer M., Huber H. T-Lymphozyten in peripherem Blut und Lymphknoten bei lymphatischen Systemerkrankungen. Schweiz Med Wochenschr. 1974 Jun 8;104(23):815–820. [PubMed] [Google Scholar]
  13. Michlmayr G., Huber H. Receptor sites for complement on certain human peripheral blood lymphocytes. J Immunol. 1970 Sep;105(3):670–676. [PubMed] [Google Scholar]
  14. Order S. E., Hellman S. Pathogenesis of Hodgkin's disease. Lancet. 1972 Mar 11;1(7750):571–573. doi: 10.1016/s0140-6736(72)90360-1. [DOI] [PubMed] [Google Scholar]
  15. Papamichail M., Brown J. C., Holborow E. J. Immunoglobulins on the surface of human lymphocytes. Lancet. 1971 Oct 16;2(7729):850–852. doi: 10.1016/s0140-6736(71)90224-8. [DOI] [PubMed] [Google Scholar]
  16. Peckham M. J. Quantitative cytology and cytochemistry of Hodgkin's tissue labelled in vivo with tritiated thymidine. Br J Cancer. 1973 Oct;28(4):332–339. doi: 10.1038/bjc.1973.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Schick P., Trepel F., Theml H., Benedek S., Trumpp P., Kaboth W., Begemann H., Fliedner T. M. Kinetics of lymphocytes in Hodgkin's disease. Blut. 1973 Oct;27(4):223–235. doi: 10.1007/BF01637435. [DOI] [PubMed] [Google Scholar]
  18. Weiner M. S., Bianco C., Nussenzweig V. Enhanced binding of neuraminidase-treated sheep erythrocytes to human T lymphocytes. Blood. 1973 Dec;42(6):939–946. [PubMed] [Google Scholar]
  19. Wilson J. D., Nossal G. J. Identification of human T and B lymphocytes in normal peripheral blood and in chronic lymphocytic leukaemia. Lancet. 1971 Oct 9;2(7728):788–791. doi: 10.1016/s0140-6736(71)92741-3. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES