TABLE 1.
Macaques and purified IgG infused
| Animals | Chimp IgG administered (mg/kg) | Calculated plasma IgG concn (μg/ml)a | Observed plasma IgG concn at 24 h (mean ± SD; μg/ml) | Neutralizing titer in plasma |
|---|---|---|---|---|
| 98P031 | 297 | 5,900 | 5,932 ± 770 | 1:123 |
| 98P049 | 297 | 5,900 | 7,687 ± 1,177 | 1:123 |
| 98P024 | 149 | 2,980 | 2,643 ± 241 | 1:40 |
| 98P043 | 149 | 2,980 | 2,199 ± 797 | 1:40 |
| 98P023 | 74 | 1,480 | 1,278 ± 157 | 1:15 |
| 98P046 | 74 | 1,480 | 1,507 ± 148 | 1:18 |
| 98P045 | 74 | 1,480 | 1,905 ± 366 | 1:18 |
| 98P021 | 37 | 740 | 724 ± 180 | 1:13 |
| 98P061 | 37 | 740 | 591 ± 137 | 1:12 |
| 98P035 | 18.6 | 380 | 399 ± 104 | 1:7 |
| 98P042 | 18.6 | 380 | 333 ± 82 | 1:6 |
| 96P082 | 18.6 | 380 | 409 ± 82 | 1:7 |
| 96P076 | 9.3 | 180 | 124 ± 7 | 1:3 |
| 96P081 | 8.9 | 180 | 149 ± 42 | 1:4 |
| 96P088 | 10.2 | 180 | 164 ± 23 | 1:4 |
| 98P033 | 34.5 (naïve IgG) | Not done | NDb | ND |
| 98P056 | 34.5 (naïve IgG) | Not done | ND | ND |
a
Plasma volume is calculated as 5% of the body weight.
b
ND, none detected.