TABLE 1.
Isolate or patient | Source | Resistance-associated mutation(s)a
|
Plasma HIV-1 RNA level (copies/ml) | |
---|---|---|---|---|
PR | RT | |||
VA-MH-001 | Plasma | 63P | None | 353,900 |
VA-MH-003 | Plasma | None | 184V | 2,618 |
VA-MH-004 | Plasma | None | 67N, 70R, 103N, 184V, 219Q | 1,279 |
VA-MH-007 | Plasma | 36I | None | 28,881 |
VA-MH-009 | Plasma | 10I, 63P | 103N, 184V, 215F | 43,525 |
018-027-001 | Plasma | 30N, 36I, 63P | 67N, 103N | 10,259 |
018-027-002 | Plasma | 35D, 46L, 63P | 118I | 212,343 |
018-027-003 | Plasma | 10F, 30N, 63P, 88D | 41L, 118I, 184V, 215Y | 20,722 |
018-027-004 | Plasma | 63P | 103N | 156,790 |
018-027-005 | Plasma | 63P | 41L, 44D, 67N, 69D, 118I, 210W, 215D/Y | 13,451 |
018-027-006 | Plasma | 10I | None | 118,334 |
018-027-007 | Plasma | 10I, 54V, 63P, 84V | 41L, 74V, 103N, 106A, 108I, 181C, 190A, 210W, 215N/S/Y | 2,535,030 |
018-027-008 | Plasma | 63P | None | 6,288 |
018-027-009 | Plasma | 10I, 36I, 46I, 48V, 82A | 41L, 62V, 75T, 106I, 118I, 181C, 184V, 188L, 215F | 526,314 |
018-027-010 | Plasma | 10I, 36I, 54V, 63P, 71V, 82A, 84V, 90M | 41L, 44D, 67N, 69D, 103N, 108I, 184V, 210W, 215Y | 31,797 |
PE-009-028c | IMC | 20R, 63P, 77I, 90M | 181C, 184V, 215N/S/Y | NAb |
13-021-027 | IMC | 30N, 90M | 181C, 215Y | NA |
Notation designates codon and altered amino acid residue within HIV-1 PR and RT.
NA, not applicable.
Sample PE-009-028 was a 1:1 mixture of wild-type and mutant IMC.