Table 3.

The statistical parameters of combinations of core elements. Combination name (col. 1); position of the center of the first element of the combination in bp (col. 2); distance between the centers of the elements in bp (the suggested synergetic distances marked by bold font (col. 3); the percentage (%) (col. 4); the absolute number (N) (col. 5); statistical significance of over-representation of promoters having this combination at respective positions with distance as in col. 3 (col. 6); and respective P-values (col. 7). The P-values were calculated as for the Table 1. The P-values < 0.001 are commonly considered to be extremely statistically significant, and those <0.01 – as very statistically significant.

1. Combination	2. Position	3. Distance	4. %	5. N	6. SS	7. P-value
Inr_DPE	-1 - +9	25	0.77	26	-4.8
		26	1.33	45	-3.7
		27	11.8	401	31.2	<0.0001
		28	1.03	35	-4.8
		29	0.77	26	-4.0
Inr_MTE	-1 - +9	15	0.41	14	-3.0
		16	1.6	55	3.3
		17	3.0	101	10.0
		18	0.35	12	-3.8
		19	0.64	22	-1.3
		16–17	4.3	147	8.7	<0.0001
MTE_DPE	17 – 26	9	0.09	3	-2.1
		10	0.97	33	7.3	<0.0001
		11	0.32	11	0.7
		12	0.12	4	-1.0
		13	0.06	2	-0.3
TATA_Inr	-33 - -23	29	1.4	46	-2.8
		30	2.4	83	1.8
		31	3.0	135	8.6
		32	4.8	163	13.9
		33	2.0	68	2.2
		34	1.7	58	1.7
		35	1.1	36	-1.0
		30–34	11.5	389	9.7	<0.0001
TATA_DPE	-33 - -23	57	0.44	15	-1.1
		58	0.80	27	2.1
		59	0.83	28	3.2
		60	0.56	19	1.7
		61	0.32	11	0.1
		58–60	1.9	66	3.2	0.0014
TATA_MTE	-33 - -23	46	0.12	4	-1.4
		47	0.44	15	2.3
		48	0.35	12	1.2
		49	0.41	14	2.0
		50	0.12	4	-1.4
		47–49	1.1	37	2.6	0.0093