Table 2.
Adjusted1) associations of 10 cytokine polymorphisms with self-reported hay fever in the ECRHS-Basel Study.
| Genotype | cases/controls2) | Odds Ratio | 95% Confidence Interval | P-value | |
| IL4 (-589C>T) | CC | 140/89 | 1 | -- | -- |
| rs2243250 | CT | 47/31 | 0.99 | 0.58 – 1.68 | 0.98 |
| TT | 5/5 | 0.56 | 0.16 – 2.03 | 0.38 | |
| IL4R Q576R (A>G) | AA | 128/71 | 1 | -- | -- |
| rs1801275 | AG | 58/45 | 0.68 | 0.42 – 1.13 | 0.12 |
| GG | 5/5 | 0.59 | 0.16 – 2.11 | 0.39 | |
| IL6(-174G>C) | GG | 65/33 | 1 | -- | -- |
| rs1800795 | GC | 97/66 | 0.77 | 0.45 – 1.30 | 0.32 |
| CC | 28/25 | 0.58 | 0.29 – 1.15 | 0.12 | |
| IL10 (-1082G>A) | GG | 60/48 | 1 | -- | -- |
| rs1800896 | GA | 96/50 | 1.58 | 0.94 – 2.6 | 0.08 |
| AA | 36/26 | 1.15 | 0.61 – 2.18 | 0.66 | |
| IL10 (-819C>T) | CC | 102/71 | 1 | -- | -- |
| rs1800871 | CT | 77/42 | 1.26 | 0.77 – 2.04 | 0.35 |
| TT | 11/12 | 0.64 | 0.27 – 1.54 | 0.32 | |
| IL12p40(1188A>C) | AA | 114/74 | 1 | -- | -- |
| rs3212227 | AC | 69/44 | 0.99 | 0.61 – 1.59 | 0.95 |
| CC | 9/6 | 1.05 | 0.36 – 3.09 | 0.93 | |
| IL13 R130Q (A>G) | GG | 127/82 | 1 | -- | -- |
| rs20541 | GA | 57/38 | 0.96 | 0.58 – 1.58 | 0.87 |
| AA | 6/4 | 0.99 | 0.27 – 3.68 | 0.99 | |
| IL18(-137G>C) | GG | 101/55 | 1 | -- | -- |
| rs187238 | GC | 73/54 | 0.75 | 0.46 – 1.22 | 0.25 |
| CC | 18/15 | 0.65 | 0.30 – 1.39 | 0.27 | |
| TNF(-308G>A) | GG | 135/84 | 1 | -- | -- |
| rs1800629 | GA | 53/35 | 0.94 | 0.57 – 1.57 | 0.83 |
| AA | 4/4 | 0.58 | 0.14 – 2.40 | 0.45 | |
| CD14 (-159C>T) | CC | 49/41 | 1 | -- | -- |
| rs2569190 | CT | 89/55 | 1.36 | 0.79 – 2.32 | 0.26 |
| TT | 51/26 | 1.64 | 0.88 – 3.09 | 0.12 |
1) Adjusted for age and gender.
2) Hay fever cases answered yes to 'Have you ever had a problem with sneezing or a runny nose or a blocked nose when you did not have a cold?', irrespective of self-reported asthma or eczema. Non-atopic controls were free of self-reported hay fever, self-reported eczema and physician-diagnosed asthma.