Table 4.
Adjusted1) association of IL6(-174G>C) and IL18(-137G>C) with hay fever2) in the SAPALDIA Cohort Study.
| Hay fever | |||||
| Genotype | cases/controls3) | Odds Ratio | 95% Confidence Interval | P-value | |
| IL6(-174G>C) | GG | 393/1112 | 1 | -- | |
| GC | 537/1386 | 1.1 | 0.95 – 1.29 | 0.21 | |
| CC | 169/451 | 1.04 | 0.84 – 1.28 | 0.74 | |
| IL18(-137G>C) | GG | 555/1619 | 1 | -- | |
| GC | 468/1117 | 1.24 | 1.07 – 1.43 | 0.004 | |
| CC | 82/217 | 1.08 | 0.82 – 1.42 | 0.60 | |
1) Adjusted for age and gender. 2) Self-reported hay fever cases answered yes to 'Have you ever had a problem with sneezing or a runny nose or a blocked nose when you did not have a cold?', irrespective of self-reported asthma or eczema. 3) Non-atopic controls were free of self-reported hay fever, self-reported eczema and physician-diagnosed asthma. 4) Controls had total IgE ≤ 100 kU/L or were negative for all specific allergen tested (Phadiatop).