TABLE 3.
Antifungal effects of H2K4b
| Fungal species | MICa
|
|
|---|---|---|
| μg/ml | μM | |
| C. albicans 10231 | 100 | 9 |
| C. albicans 76615 | 100 | 9 |
| C. albicans 90259 | 100 | 9 |
| C. albicans MYA-1237 | 100 | 9 |
| C. albicans MYA-576 | 100 | 9 |
| C. parapsilosis | 125 | 10.8 |
| C. glabrata | 75 | 6.7 |
| C. tropicalis | 37.5 | 3.4 |
| C. krusei | 37.5 | 3.4 |
| C. kefyr | 100 | 9 |
| T. cutanuem | 75 | 6.7 |
a
To determine the MIC of H2K4b, increasing amounts of the peptide (0, 0.5, 2.5, 5, 10, 15, 25, 37.5, 50, 75, 100, 125, and 150 μg/ml) were added to the YM culture containing 5 × 105 CFU/ml of the fungal species. The fungi were rotated at room temperature until the optical density at 600 nm of the untreated control group was between 0.5 and 1.0.