TABLE 4.
Effects of patterns of branched polymers
| Fungal species | MIC [μg/ml (μM)]a
|
||||
|---|---|---|---|---|---|
| H2L4b | H2K(L4)4b | H2K(L5)4b | H3K4b | H2K4b | |
| T. cutaneum | 50 (5) | 50 (4.6) | 15 (1.4) | NDb | 75 (6.7) |
| C. albicans | —c | — | — | 150 (15) | 100 (9) |
| C. tropicalis | 15 (1.5) | 15 (1.4) | 15 (1.4) | ND | 37.5 (3.4) |
| C. kefyr | — | — | — | 125 (12.5) | 100 (9) |
a
The MICs of several polymers [H2L4b, H2K(L4)4b, H2K(L5)4b, H3K4b, and H2K4b] against several fungi were determined The polymers at concentrations between 15 μg/ml and 150 μg/ml were added to YM cultures containing fungi (5 × 105 CFU/ml), and the tubes were rotated at room temperature as described in Materials and Methods.
b
ND, not done.
c
—, MIC > 150 μg/ml.