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(A) Pathway model of 3TC transport and metabolism in PBMCs denoting 3TC uptake and efflux and the formation and degradation by phosphatases for 3TCMP, 3TCDP, and 3TCTP. (B) Final model for transport and intracellular metabolism of 3TC obtained from the population analysis of the ex vivo data. See the text for the rationale for the inclusion of M as an intermediate metabolite and simplifying assumptions for A and B.
