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Population means and standard deviations of 3TC systemic pharmacokinetic parameters
| Parameter (unit) | Population mean | Population SD (CV%) |
|---|---|---|
| CL/Fb (liters h−1) | 47.8 | 21.3 (45) |
| k12 (h−1) | 0.061 | 0.047 (77) |
| k21 (h−1) | 0.060 | 0.040 (67) |
| V/Fc (liters) | 197 | 103 (52) |
| σ3TC | 0.40 (0.33-0.49)a |
Median value (95% credibility interval).
Apparent clearance.
Apparent volume of distribution of the central compartment.
