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Population parameter estimates for 3TC metabolism in PBMCs from HIV-1-infected adolescents
| Parameter (unit) | Estimate
|
|
|---|---|---|
| Population mean | Population SD (CV%) | |
| Km (pmol/106 cells) | 0.58 | 0.33 (57) |
| Vmax (pmol/106 cells/h) | 1.95 | 0.96 (49) |
| kMP-3TC (h−1) | 2.02 | 0.90 (45) |
| RDP/MP (−) | 6.65 | 2.98 (45) |
| RTP/DP (−) | 1.02 | 0.89 (87) |
| kTP-M (h−1) | 0.16 | 0.092 (58) |
| kM-MP (h−1) | 0.46 | 0.20 (43) |
| σ3TCMP | 0.87 (0.74-1.05)a | |
| σ3TCDP | 0.63 (0.54-0.76)a | |
| σ3TCTP | 0.64 (0.55-0.77)a | |
Median value (95% credibility interval).
