TABLE 2.

Mutations detected among INH^r and INH^s isolates

Mutationa	No. of isolates				Mutationa	No. of isolates
	INHr	INHs	Total			INHr	INHs	Total
katG mutations					−46 g→A	14	11	25
123-128-?b	2		2		−46 ΔG		1	1
R128P (cgg→cCg)	1		1		−39 c→T	4		4
N138H (aac→Cac)	1		1		−30 c→T	1		1
N138D (aac→Gac)	2		2		−15 c→T	1		1
N138S (aac→aGc)	1		1		−12 c→T	2		2
A172T (gcg→Acg)	2		2		−10 c→A	2		2
S315R (agc→agG)	1		1		−10 c→G	2		2
S315T (agc→aCc)	184		184		−10 c→T	7		7
S315N (agc→aAc)	9		9		−9 g→A	2	1	3
S315I (agc→aTc)	6		6		−9 g→?b	2		2
S315T (agc→aCA)	21		21		−8 a→?b	1		1
G316D (ggc→gAc)	1		1		−6 g→A	4		4
G316S (ggc→Agc)		2	2		−4::T	3		3
W321G (tgg→Ggg)	1		1		ORF mutations
L336P (ctg→cGg)	1		1		T5I (acc→aTc)	1		1
R515C (cgc→Tgc)	1		1		D73H (gac→Cac)	7	6	13
L587P (ctg→cCg)		1	1		Total	54	19	73
D735A (gac→gCc)	1		1
Total	235	3	238		inhA mutations
					Promoter mutationsd
kasA mutations					−17 g→T	3	1	4
D66N (gat→Aat)	1	1	2		−15 c→T	31		31
G269S (ggt→Agt)	36	87	123		−8 t→A	3		3
G312S (ggc→Agc)	7	12	19		−8 t→C	1		1
Total	44	100	144		ORF mutations
					I21V (atc→Gtc)	1		1
ndh mutations					I21T (atc→aCc)	2		2
V18A (gtg→gCg)	12	16	28		I47T (att→aCt)		1	1
R268H (cgc→cAc)	2		2		S94A (tcg→Gcg)	5		5
Total	14	16	30		I194T (atc→aCc)	2	1	3
					Total	48	3	51
oxyR-ahpC mutations
Promoter mutationsc					All mutations	395	141	536
−67 g→A	1		1

^aThe mutant codon is indicated, followed by the nucleotide change, shown in capital letters. When the mutation occurs in an intergenic region, the nucleotide change is indicated relative to the start site of the following ORF.

^bSequences that were confirmed to be mutants by a molecular beacon assay but whose exact mutation is not known because sequencing results were inconclusive or DNA was unavailable for sequencing.

^cPositions in the ahpC promoter are situated relative to the transcriptional start residue.

^dPositions in the inhA promoter are situated relative to the start of the mabA ORF (mabA is the first gene in the mabA-inhA operon).