TABLE 4.

Frequency and distribution of multiple mutations in individual M. tuberculosis isolates

Gene	Location of mutation	No. (%) of isolates with mutations in indicated gene location
		katG			inhA			ahpC				kasA			ndh
		All	Position 315	Positions other than 315	All	Promoter	ORF	All	Promoter	ORF	D73H	All	Position 269	Position 312
katG	All	238 (100)	221 (100)	17 (100)	5 (11)	2 (5)	3 (25)	20 (27)	14 (24)	6 (43)	5 (38)	34 (24)	29 (24)	5 (26)	9 (30)
	Position 315	221 (93)	221 (100)	0	5 (11)	2 (5)	3 (25)	15 (21)	9 (15)	6 (43)	5 (38)	34 (24)	29 (24)	5 (26)	9 (30)
	Positions other than 315	17 (7)	0	17 (100)	0	0	0	5 (7)	5 (8)	0	0	0	0	0	0
inhA	All	5 (2)	5 (2)	0	46 (100)	39 (100)	12 (100)	6 (8)	6 (10)	0	0	5 (3)	3 (2)	2 (11)	1 (3)
	Promoter	2 (1)	2 (1)	0	39 (85)	39 (100)	5 (42)	6 (8)	6 (10)	0	0	3 (2)	1 (1)	2 (11)	0
	ORF	3 (1)	3 (1)	0	12 (26)	5 (13)	12 (100)	1 (1)	1 (2)	0	0	3 (2)	2 (2)	1 (5)	1 (3)
ahpC	All	20 (8)	15 (7)	5 (29)	6 (13)	6 (15)	1 (8)	73 (100)	59 (100)	14 (100)	13 (100)	0	0	0	2 (7)
	Promoter	14 (6)	9 (4)	5 (29)	6 (13)	6 (15)	0	59 (81)	59 (100)	0	0	0	0	0	1 (3)
	ORF	6 (3)	6 (3)	0	0	0	1 (8)	14 (19)	0	14 (100)	13 (100)	0	0	0	1 (3)
	D73H	5 (2)	5 (2)	0	0	0	0	13 (18)	0	13 (93)	13 (100)	0	0	0	0
kasA	All	34 (14)	34 (15)	0	5 (11)	3 (8)	3 (25)	0	0	0	0	144 (100)	123 (100)	19 (100)	0
	Position 269	29 (12)	29 (13)	0	3 (7)	1 (3)	2 (17)	0	0	0	0	123 (85)	123 (100)	0	0
	Position 312	5 (2)	5 (2)	0	2 (4)	2 (5)	1 (8)	0	0	0	0	19 (13)	0	19 (100)	0
ndh	All	9 (4)	9 (4)	0	1 (2)	0	1 (8)	2 (3)	1 (2)	1 (7)	0	0	0	0	30 (100)