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. 2006 Aug;50(8):2814–2819. doi: 10.1128/AAC.00220-06

TABLE 2.

Cytokine levels in lungs of mice infected and subjected to chemotherapy and/or P10 vaccination after 30 days of infection

Treatment group Cytokine level (pg/ml) at the indicated time (days) of infectiona
IL-4
IL-10
IL-12
IFN-γ
60 120 60 120 60 120 60 120
Sham 752 ± 78 845 ± 85 4,680 ± 511 3,852 ± 665 13,211 ± 958 11,789 ± 1,214 712 ± 222 648 ± 65
Adjuvant 988 ± 111 854 ± 70 4,997 ± 488 4,221 ± 326 15,021 ± 1,012 10,121 ± 1,014 911 ± 111 914 ± 102
Untreated 2,654 ± 112 2,312 ± 522 16,021 ± 612 10,520 ± 1,584 38,021 ± 1,562 29,522 ± 2,011 2,615 ± 214 3,852 ± 545
P10 1,510 ± 88 1,121 ± 232 11,115 ± 522 6,250 ± 1,128 78,521 ± 2,123 63,160 ± 3,602 5,741 ± 612 6,412 ± 1,369
Fluconazole 3,120 ± 166# 3,321 ± 665# 24,021 ± 1,021# 27,321 ± 2,358# 59,564 ± 1,855 63,555 ± 4,312 2,985 ± 251 3,621 ± 511
Fluconazole + P10 1,712 ± 98 2,011 ± 501 14,333 ± 633 22,619 ± 1,545 77,512 ± 2,213* 88,888 ± 3,101* 6,021 ± 452* 9,021 ± 741*
Ketoconazole 5,312 ± 615# 3,842 ± 852# 26,313 ± 1,245# 14,222 ± 2,354# 45,326 ± 2,651 52,321 ± 2,988 3,011 ± 365 2,014 ± 636
Ketoconazole + P10 3,021 ± 188 2,011 ± 654 20,231 ± 999 11,050 ± 1,655 76,582 ± 2,365* 56,500 ± 4,021* 7,112 ± 522* 8,844 ± 766*
Itraconazole 3,011 ± 318 3,015 ± 925# 19,744 ± 823# 17,455 ± 2,011# 59,621 ± 1,025 54,114 ± 3,022 2,744 ± 329 2,113 ± 527
Itraconazole + P10 2,633 ± 215 1,855 ± 357 13,212 ± 655 11,456 ± 1,045 79,625 ± 1,653* 44,112 ± 2,958 6,623 ± 444* 9,571 ± 1,712*
Amphotericin B 1,546 ± 274 1,879 ± 603 17,100 ± 555# 14,101 ± 1,789 33,265 ± 2,012 44,101 ± 3,012 3,111 ± 363 4,511 ± 951
Amphotericin B + P10 1,115 ± 63 2,011 ± 518 11,011 ± 456 13,011 ± 1,412 68,222 ± 2,322* 64,111 ± 5,114* 7,751 ± 454* 6,255 ± 1,874*
Trimethoprim-sulfamethoxazole 5,311 ± 512# 5,845 ± 1,232# 23,121 ± 1,066# 21,456 ± 1,654# 33,665 ± 1,988 38,258 ± 2,145 2,655 ± 388 2,487 ± 358
Trimethoprim-sulfamethoxazole + P10 2,955 ± 311 3,695 ± 989 15,321 ± 633 14,258 ± 1,658 69,852 ± 2,011* 60,115 ± 2,532* 5,111 ± 522* 10,421 ± 654*
a

Boldface indicates a predominat Th-1 or Th-2-like response according to the cytokines produced (IL-12/IFN-γ or IL-4/IL-10, respectively). *, statistically significant difference (P < 0.05) relative to mice treated only with the drug; #, statistically significant difference (P < 0.05) relative to mice immunized with P10 and treated with the drug. Values are means ± standard deviations of measurements from 5 to 10 animals in each group. The whole experiment was repeated twice with reproducible results.