TABLE 1.
Antiviral activities and selectivities of alkoxyalkyl esters of (S)-HPMPA against HIVLAI
| Compound | Efficacy (EC50, μM)a | Cytotoxicity (CC50, μM)a | Selectivity indexb |
|---|---|---|---|
| (S)-HPMPA | 77.5 ± 17.1 (4) | >100 (3) | >1.29 |
| HDP-(S)-HPMPA | 0.007 ± 0.007 (4) | 1.0 ± 0.91 (3) | 143 |
| ODE-(S)-HPMPA | 0.0004 ± 0.0004 (4) | 0.03 ± 0.02 (3) | 75 |
| OLE-(S)-HPMPA | 0.008 ± 0.01 (3) | 0.20 ± 0.07 (3) | 25 |
| OLP-(S)-HPMPA | 0.107 ± 0.1 (3) | 7.0 ± 5.3 (3) | 65 |
a
Data are expressed as means ± standard deviations. The numbers in parentheses represent the number of independent determinations.
b
Selectivity index, CC50/EC50.