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Antiviral activities of HDP-(S)-HPMPA and ODE-(S)-HPMPA against HIVLAI and drug-resistant HIV variants
| Compound | EC50 (nM) againsta:
|
||||
|---|---|---|---|---|---|
| HIV-1LAI | 4×AZT | M184V | K65R | K103N | |
| HDP-(S)-HPMPA | 7.0 | 5.0 | 30 | 160 | 20 |
| ODE-(S)-HPMPA | 0.40 | 0.01 | 0.037 | 3.0 | 0.35 |
4×AZT is an AZT-resistant variant having HIV reverse transcriptase mutations D67N, K70R, T215Y, and K219Q. Data are the averages of two to four determinations.
