TABLE 3.
Drug resistance in old versus modern Beijing genotype strains
| Drug resistancea | No. (%) of strains
|
P value | Odds ratio (95% confidence interval) | |
|---|---|---|---|---|
| Old Beijing sublineage (n = 27) | Modern Beijing sublineage (n = 86) | |||
| S (1944) | 9 (33.3) | 32 (37.2) | 0.7 | 0.84 (0.34, 2.10) |
| H (1952) | 17 (63.0) | 47 (54.7) | 0.5 | 1.41 (0.58, 3.43) |
| R (1970s) | 21 (77.8) | 47 (54.7) | 0.03 | 2.90 (1.07, 7.91) |
| E (1960s) | 9 (10.5) | |||
| Z (1980s) | 6 (22.2) | 8 (9.3) | 0.08 | 2.79 (0.87, 8.91) |
| Any drug resistance | 21 (77.8) | 56 (65.1) | 0.2 | 1.88 (0.68, 5.15) |
| MDR | 17 (63.0) | 38 (44.2) | 0.09 | 2.15 (0.88, 5.23) |
a
In parentheses is the time of introduction of the particular drug for anti-TB therapy (10). S, STR; H, INH; R, RIF; E, EMB, Z, PZA; MDR, resistance to at least RIF and INH.