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Growth-inhibitory effect of AG205 against S. pneumoniae strains. (A) S. pneumoniae IP692; (B) S. pneumoniae ATCC 49619; (C) S. pneumoniae KU197; (D) S. pneumoniae KU197 mutant with FabK(Ala141Ser). Growth curves for drug-free controls are shown with no symbol. AG205 was used at 1 (•), 2 (▴), 4 (▪), and 8 (×) μg/ml for the clinical isolates (A to C) and at 2 (▴), 4 (▪), 8 (×), and 16 (⧫) μg/ml for the mutant strain (D).
