TABLE 1.

Deduced amino acid substitutions in FabK and susceptibility to AG205 for clinical isolates of S. pneumoniae

No. of strains	Amino acid substitutiona at:			No. of isolates showing a MIC (μg/ml)b of:
	V161	E276	T318	1	2	4	8	16	>16
1						1
3			A			1			2
3		D			2	1
1		D	A		1
10	I	D		1	2	6			1
12	I	D	A		1	6	2		3

^aFabK sequences were compared to that of the R6 strain (GenBank accession no. AE008418).

^bMIC testing was performed with brain heart infusion broth.