TABLE 1.

Target inhibition and MIC data for pyrrolidinedione derivatives

Compound	IC50 (nM) for S. aureus 133a	MIC (μg/ml)		IC50 (nM) for E. colia	MIC (μg/ml)
		S. aureus 133	S. pneumoniae G9A		E. coli HN818b	E. coli Neumann
1	96	8	32	6	4	32
2	91	2	16	4	1	16
3	264	1	32	14	2	64
4	68	0.25	32	7	1	64
5	48	0.06	4	11	1	16
6	44	0.03	1	4	1	32
7	33	0.01	0.25	2	0.5	16

^aTest results were obtained with the recombinant ACC-carboxyltransferases from E. coli and S. aureus, respectively.

^bacrA efflux pump deletion strain.