TABLE 3.

Summary of the CD analysis of several DCD-derived and control peptides in different solutions: distilled water, 10 mM sodium phosphate (NaP), 10 mM NaP with 10 or 150 mM NaCl, TFE, or in the presence of unilamellar liposomes, such as DOPC and DOPC-DOPG (1:1 molar ratio)^a

Peptide	Solution	Secondary structure (%)
		α-Helix	β-Sheet	Turn	Random coil
DCD-1L	dH2O	0.0	28.8	16.4	54.9
	10 mM NaP	0.0	17.5	20.5	62.0
	10 mM NaP-10     mM NaCl	0.0	19.1	19.4	61.4
	10 mM NaP-150     mM NaCl	0.0	32.1	0.0	67.9
	DOPC	0.0	35.2	9.8	55.0
	DOPC-DOPG	0.0	27.8	15.4	56.8
	60% TFE	34.5	27.2	0.0	38.3
LEK-45	dH2O	0.0	30.3	16.1	53.6
	10 mM NaP	0.0	13.6	21.2	62.2
	10 mM NaP-10     mM NaCl	0.0	17.0	19.5	63.5
	10 mM NaP-150     mM NaCl	0.0	41.5	0.0	58.5
	60% TFE	28.0	31.0	0.0	41.0
SSL-23	dH2O	0.0	38.2	14.8	47.0
	10 mM NaP	0.0	23.8	18.4	57.7
	DOPC	0.0	13.7	21.5	64.8
	DOPC-DOPG	2.2	49.2	3.8	44.8
	60% TFE	14.1	40.8	4.9	49.2
	80% TFE	32.9	27.6	0.0	39.5
SSL-25	dH2O	0.0	22.3	20.7	57.0
	60% TFE	31.1	27.1	0.0	41.8
SSL-29	dH20	0.0	24.3	20.3	55.4
	60% TFE	12.2	46.2	0.0	41.7
LL-37	10 mM NaP	50.9	6.0	16.6	26.5
	DOPC	54.1	6.4	14.0	25.5
	DOPC-DOPG	80.2	0.0	8.7	11.0
DPI	dH2O	0.0	34.3	15.4	50.3
	10 mM NaP	0.0	25.8	19.4	54.8
	DOPC-DOPG	0.0	29.7	19.1	51.2
	60% TFE	9.6	42.0	6.0	42.5

^aData are based on Jasco secondary structure estimation software. dH₂O, distilled water.