Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Kinetic parameters of M. tuberculosis class A β-lactamase with different antibiotics as substrates
| Class | Antibiotic | kcat (s−1) | Km (μM) | kcat/Km (mM−1 s−1) | Ki (μM) |
|---|---|---|---|---|---|
| Penicillin | Ampicillin | 18.5 ± 0.9 | 63 ± 7 | 293 | |
| Cephalosporin | Cephalothin | 12.1 ± 1.1 | 117 ± 14 | 103 | |
| Cefoxitin | 1.1 ± 0.3 | 195 ± 15 | 5.6 | ||
| Ceftazidime | 0.2 ± 0.1 | 593 ± 29 | 0.4 | ||
| Carbapenem inhibitor | Meropenem | 0.9 ± 0.3 | 279 ± 23 | 3.2 | |
| Clavulanate | 2.4 ± 1.1 |
