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Flow cytometry was used to determine the expression of CCR9 and integrin β7, associated with homing to the gut, on CD4+/CD45RA- memory T cells in paired blood and CSF samples from patients with non-inflammatory neurological diseases. Memory T cells expressing CCR9 and integrin β7 were detected at comparable numbers in blood (A) and CSF (B), indicating that gut-homing memory T cells readily access the CNS.
