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Endogenous rate of AP sites formation in intact IMR90 cells. Senescent and young IMR90s (2 × 106/ml) in PBS/5 mM glucose were treated for different intervals with 5 mM ARP at 37°C. Then, free ARP was washed out followed by isolation of DNA, and the level of AP sites was determined as described in Materials and Methods. The values are mean ± SE. *, P < 0.05; **, P < 0.01.
