FIG. 3.

Development of lung pathology in mice 40 days after challenge with M. bovis. Lungs of nonvaccinated mice show marked foci of an existing tuberculosis infection (C) and development of necrosis and decreased lung aeration (A). Mice vaccinated with Flu/ESAT-6 vectors show lesser signs of lung pathology (D) and single and small infiltrative foci and aerated lungs (B). The images show representative views of the lungs from vaccinated and control groups of mice. In the control group of mice, the most pronounced pathological changes (large necrosis foci) are shown. Magnification for panels A and B, ×280.