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The virulence of the conditional C. albicans FBA1 mutants is attenuated in the mouse model of systemic candidiasis. Fungal burdens were measured in the kidneys of mice humanely sacrificed 5 days after injection with 2.5 × 105 C. albicans cells. Results for FBA1/FBA1 (ARC106), MET3-FBA1/FBA1 (ARC102), MET3-FBA1/fba1 A (ARC103), MET3-FBA1/fba1 B (ARC104), and the ura3/ura3/MET3-URA3 control (TY 1) are shown. Sentinels, no fungal cells injected.
